Effect of preexisting human leukocyte antigen donor-specific antibodies especially human leukocyte antigen-DQ on kidney transplant outcome

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منابع مشابه

Human leukocyte antigen class II antibodies and transplant outcome.

During recent years, increasing evidence has accumulated that preformed antidonor human leukocyte antigen (HLA) class II antibodies represent significant risk factors for transplant dysfunction and failure (1– 6). Also, the posttransplant development of anticlass II antibodies is associated with a higher incidence of acute and chronic rejection (7–14). In this issue, the report by Issa et al. (...

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The complexity of human leukocyte antigen (HLA)-DQ antibodies and its effect on virtual crossmatching.

BACKGROUND We previously reported that in patients possessing human leukocyte antigen (HLA)-DQ-directed antibodies, the target molecule may include the patient's own DQβ chain if it is paired with non-self-DQα chain, thus forming a different DQ target. Herein, we sought to assess the breadth of this phenomenon. METHODS Serum samples from 104 patients awaiting kidney transplantation, known to ...

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Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

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Open-Access: This article is an open­access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY­NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non­commercially, and license their derivative works on different terms, prov...

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ژورنال

عنوان ژورنال: Korean journal of transplantation

سال: 2022

ISSN: ['2671-8790', '2671-8804']

DOI: https://doi.org/10.4285/atw2022.f-2255